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KMID : 1377020170140030221
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Tissue Engineering and Regenerative Medicine
2017 Volume.14 No. 3 p.221 ~ p.231
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Comparison of Bio-degradation for Ridge Preservation Using Silk Fibroin-based Grafts and a Collagen Plug
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Seok Hyun
Jo You-Young
Kweon Hae-Yong
Kim Seong-Gon
Kim Min-Keun
Chae Weon-Sik
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Abstract
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A material for ridge preservation should have dimensional stability to resist bio-degradation. This study was designed to compare bio-degradation of ridge preservation materials. Collagen plug was used as a positive control. Untreated, ethanol-treated, and 4-hexylresorcinol (4HR)-treated silk plugs were used for the experimental group. Each material underwent a scanning electron microscopic exam and a Fourier transform infrared (FT-IR) spectroscopic exam. Bio-degradation was evaluated by analyzing cylindrical bony defects in rabbit tibias. There were no prominent differences in microstructure among the silk plug groups. FT-IR exam demonstrated that the ethanol- and 4HR-treated silk plug groups had enhanced β-sheet structure. All silk plug groups exhibited significantly higher residual graft than the collagen plug group 4 weeks postoperative (p < 0.05). In conclusion, silk fibroin-based ridge preservation material was less bio-degradable than a collagen plug until at least 4 weeks after grafting.
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KEYWORD
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Silk fibroin, 4-Hexylresorcinol, Ridge preservation, Bio-degradation, Plug
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